Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii
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چکیده
منابع مشابه
Biosynthesis of Sesquiterpene Lactones in Pyrethrum (Tanacetum cinerariifolium)
The daisy-like flowers of pyrethrum (Tanacetum cinerariifolium) are used to extract pyrethrins, a botanical insecticide with a long history of safe and effective use. Pyrethrum flowers also contain other potential defense compounds, particularly sesquiterpene lactones (STLs), which represent problematic allergenic residues in the extracts that are removed by the pyrethrum industry. The STLs are...
متن کاملQuantitative structure--antiprotozoal activity relationships of sesquiterpene lactones.
Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have now conducted a structure-(in-vitro)-activity study on a set of 40 STLs against T. brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum. Furthermore, cytotoxic activity ...
متن کاملHologram QSAR studies of antiprotozoal activities of sesquiterpene lactones.
Infectious diseases such as trypanosomiasis and leishmaniasis are considered neglected tropical diseases due the lack for many years of research and development into new drug treatments besides the high incidence of mortality and the lack of current safe and effective drug therapies. Natural products such as sesquiterpene lactones have shown activity against T. brucei and L. donovani, the paras...
متن کاملSesquiterpene Lactones from Achillea
The species of genus Achillea, particularly those belonging to the Achillea millefolium group have received a lot of attention so far, due to their use in traditional medicine. Among the numerous chemical compounds isolated from the A. millefolium species, the sesquiterpene lactones are usually one of the major constituents (Seaman, 1982). Continuing our chemotaxonomic examination of Bulgarian ...
متن کاملFlavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms
Human schistosomiasis, caused by trematode worms of the genus Schistosoma, is one of the most significant neglected tropical diseases, affecting more than 200 million individuals worldwide and praziquantel is the only available drug to treat this disease. Artemisia absinthium L. and Tanacetum parthenium L. are species popularly used as anthelmintics. We investigated the in vitro schistosomicida...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 2019
ISSN: 0032-0943,1439-0221
DOI: 10.1055/a-0824-1294